Trough concentration 뜻
WebTrough concentration: the concentration of drug in the blood immediately before the next dose is administered, although this does not necessarily represent the lowest concentration during a dosing interval. Minimum concentration (C min): the lowest concentration of drug in the blood following the administered dose. WebApr 9, 2024 · trough (plural troughs) A long, narrow container, open on top, for feeding or watering animals. One of Hank's chores was to slop the pigs' trough each morning and evening. Any similarly shaped container.
Trough concentration 뜻
Did you know?
WebSteady-state concentration (C ss) is defined as the time during which the concentration remains stable or consistent when the drug is given repeatedly or continuously (IV infusion).The time to reach steady-state is a function of T ½ and is achieved when the rate of the drug entering the systemic circulation equals the rate of elimination. For most drugs, … WebAug 27, 2024 · An algorithmic approach helps us to understand the role of reactive TDM and shift gears appropriately based on drug concentration and antibody levels (Figure 1).10 Target trough concentrations of at least 5 mcg/mL for infliximab and 7.5 mcg/mL for adalimumab have been historically considered to be adequate to achieve mucosal …
WebJan 21, 2024 · After the target AUC or trough level is achieved at steady state, trough levels should be checked every 2 to 5 days until completion of therapy or discharge. Check … WebMar 21, 2024 · Trough concentration may be used as a surrogate for AUC, although the acceptable target trough concentration will vary depending on dosing interval and …
Webtrough noun [C] (LOW POINT) a low point in a regular series of high and low points: Investing small amounts regularly is a good way of smoothing out the peaks and troughs of the … Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. It is a standard measurement in pharmacokinetics.
WebSynonym (s) Trough Concentration, Trough Level. A pharmacokinetic measure used to determine drug dosing. C min is the lowest concentration of a drug in the blood, cerebrospinal fluid, or target organ after a dose is given.
WebCL = constant when plasma drug concentration ([drug]p) is less than that which "saturates" the elimination system(s) CL = variable when [drug]p is at or near the Vmax of elimination … lightning cable hdmi mini usbWebInstall a service conduit of the appropriate size at the meter base. Extend the service conduit to 610 mm below grade and then securely fasten the conduit to the wall 150 mm above … peanut butter anti inflammatoryWebTrough concentrations of 5 to 10mg/L (i.e., at least two to four times the MIC) are usually considered adequate but up to 15mg/L may be required for some serious infections. Some hospitals use constant rate in-fusions of vancomycin, aiming to maintain concentrations between 15 and 25mg/L. lightning cable iphone seWebTrough concentration: the concentration of drug in the blood immediately before the next dose is administered, although this does not necessarily represent the lowest … lightning cable headphone adapterWebVedolizumab concentration greater than 15 mcg/mL at trough is associated with clinical remission, endoscopic remission, or mucosal healing in inflammatory bowel disease. Clinically significant antibodies-to-vedolizumab impact drug clearance and are associated with low (< or =15 mcg/mL at trough) or undetectable vedolizumab concentration. peanut butter ant trapWebVancomycin trough concentration is a good marker of AUC for critically ill adults without any form of dialysis. However, for patients with trough concentrations of 10-15 mg/L, AUC-guided TDM may be needed, especially for those with risk factors. lightning cable hubWebIn medicineand pharmacology, a trough levelor trough concentration(Ctrough) is the concentrationreached by a drugimmediately before the next dose is administered,[1][2]often used in therapeutic drug monitoring. The name comes from the … lightning cable for iphone 12