WebDec 1, 2024 · Daratumumab-based regimens achieve deep hematologic and organ responses, offering a new therapeutic backbone. Early identification, correct fibril typing, challenges of the very advanced patient, and lack of therapies to remove amyloid deposits remain under study, but are, as yet, elusive. WebFeb 4, 2024 · The recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was the first CD38-targeting antibody showing to be effective and safe in MM patients as monotherapy and in combination regimens, which led to its rapid implementation in clinical practice. …
Daratumumab utilization and cost analysis among patients with …
WebDaratumumab (dara) has significantly altered the therapeutic landscape of multiple myeloma (MM), especially in the relapsed setting. WebDec 2, 2016 · Background: Detection and quantification of monoclonal component (M-spike) by serum protein electrophoresis (SPE) and immunofixation (IFE) are essential for response evaluation in multiple … scraper wood finishing
daratumumab Cancer Care Ontario
WebFeb 1, 2024 · Daratumumab injection is also used in combination with lenalidomide and dexamethasone to treat patients with newly diagnosed multiple myeloma who cannot receive autologous stem cell transplant and patients with relapsed (cancer that has come back) or refractory (cancer that did not respond to treatment) multiple myeloma who have … WebSep 10, 2015 · Among patients who received second-line treatment, 28 (70%) were retreated with a rituximab-based regimen with high response rates (82% achieved at least a minor response); 12 patients (30%) were treated with alkylating agents, fludarabine, or bortezomib (67% achieved at least a minor response). WebFeb 10, 2024 · Mechanism of Action. Daratumumab is an IgG1κ human monoclonal antibody directed against CD38. CD38 is a cell surface glycoprotein which is highly expressed on myeloma cells, yet is expressed at low levels on normal lymphoid and myeloid cells (Lokhorst 2015). By binding to CD38, daratumumab inhibits the growth of CD38 … scraper woodworking